It has been suggested that the development of IVF (in vitro fertilization) and assisted reproductive technology have been the standout achievements of clinical and scientific discovery over the last century, perhaps ever. If you ask infertility patients who have benefited from IVF you would be hard-pressed to find anyone who would disagree. IVF and assisted reproductive procedures have made the impossible, possible, including the opportunity to choose the gender of your newborn. Should IVF, however, be used for gender selection or is \u2018family balancing\u2019 by IVF a step too far? Let us take a closer look.<\/p>\n\n\n\n
So, how easy is it to identify or choose the sex of a resulting child with an IVF procedure? Well, from the scientific point of view it is relatively easy, or so I am told. Here in terms most of us will understand, is how it\u2019s done. Using a very clever technique called Pre-Implantation Genetic Screening or Testing for Aneuploidy, or the more memorable abbreviation, PGT-A<\/a>, the fertility specialists are able to take a closer look at embryos to check whether there are any chromosomal abnormalities. This genetic testing is important as any chromosomal abnormality could negatively affect the chances of the embryo developing into a baby or potentially result in the baby being born with a genetic disorders. The procedure involves removing at least one cell from the embryo which is tested, without harming the embryo itself.<\/p>\n\n\n\n During the procedure the specialist undertaking the analysis will be able to determine the sex of the embryo after just a few days by counting the chromosomes. In countries where gender selection is legal and accepted it is at this point where the patient could legitimately \u2018choose\u2019 the desired gender: the boy or girl embryo.<\/p>\n\n\n\n Preimplantation genetic testing for aneuploidy has been used increasingly in IVF cycles, and results in information regarding the sex of the resulting embryos, even when the initial indication for IVF was unrelated to sex selection. This possibility of knowing the sex of the resulting embryo(s) is an option that patients may not have considered previously and for which they may have a variety of opinions. Knowledge of embryo sex at time of embryo transfer and its potential impact or lack thereof on embryo selection for transfer should be discussed at the time of informed consent for PGT-A.<\/p>\nEthics Committee of the American Society for Reproductive Medicine<\/a><\/cite><\/blockquote>\n\n\n\n In terms of reliability and accuracy PGT-A leads the field but there are a number of other techniques which are championed by some to be an effective way of enabling fertility patients to choose the sex of a baby.<\/p>\n\n\n\n One of the more commonly relied upon procedures to facilitate gender selection in IVF clinics (where it is legal) is the use of Flow Cytometry, commonly referred to as, \u2018sperm sorting\u2019. This technique which some claim has an accuracy rating of 80 to 90% involves a coloured dye being added to a sperm sample. The extent to which the dye binds to the genetic material found in the sperm can determine boy from girl. Another caveat, it can be an expensive procedure and many point to much lower accuracy figures.<\/p>\n\n\n\n There is one thing that we can agree on. Where it is legal and the procedure is undertaken by a medic or scientist, the cost of IVF procedure with gender selection is expensive. So, are there any cost-effective, reliable alternatives? Is gender selection possible without IVF treatment? Well, there are suggestions, and you take your chances regarding their supposed reliability. From timing sex to DIY gender selection kits, you have plenty of options to choose from but, unfortunately, there is no consistent evidence to show that any of them actually work anf get high success rates.<\/p>\n\n\n\n Reproductive medicine has given patients two procedures: PGT-A and sperm sorting to enable those seeking to select the gender of their baby (for medical or non medical reasons) but for a number of reasons (morally, ethically, and legally) access to these procedures depends on the country in which you are undergoing any form of assisted reproduction treatments.<\/p>\n\n\n\n There are many reasons why many couples would want or need to choose the gender. For the majority, the simplest way to do this is to select a clinic that offers the genetic testing of embryos and documents the sex of the embryo(s) on the test results. Complicated? Yes, it is and that\u2019s why it is so important to do your research and seek independent advice when you are considering so-called IVF family balancing or gender selection for any reason. We have put together a list which will help you begin the search for countries that have specific legislation in place regarding IVF procedure and gender selection as well as those who are likely to provide such information on PGT-A test results on a clinic by clinic basis.<\/p>\n\n\n\n It would appear from this small sample of countries that legislation regarding IVF and gender selection is firmly sat in the \u2018unlawful\u2019 camp, but this is only part of the picture. As we have learnt, legislation may not be wholly specific or backed up by mandatory guidance for infertility clinics. It is a procedure therefore that might be offered on a clinic by clinic basis and one which is very much dependent on the particular circumstances of the patient(s).<\/p>\n\n\n\n The cost of the IVF gender selection procedure is exactly the same as the cost of any type of the IVF cycle where the embryo biopsy and PGT-A using NGS technique is used and may range from EUR8,000 (Europe, Mexico if possible) to EUR 30,000 (in the US) depending on the destination country.<\/p>\n\n\n\n The cost of IVF treatment in popular IVF destinations may vary, so patients need to make a decision based on their budget and the country where IVF cycle for gender selection might be allowed. <\/p>\n\n\n\n Parents to be may wonder why this practice is still offered to, or requested by, IVF patients when legislation would suggest that it should not be. A mercenary answer would be profit, from a IVF treatment providers point of view offering a gender selection service may be lucrative (procedures don\u2019t come cheap) \u2013 more patients, more income.<\/p>\n\n\n\n The majority of treatment providers are not that mercenary, however, and merely want to offer their patients a service which is tailored to meet their specific requirements.<\/p>\n\n\n\n There are intended parents who simply want to choose a specific sex of their baby for personal reasons or cultural notions of family balancing. Also many couples who have a genetic disorder which might be passed more readily to a son or daughter who would seek to determine the sex of a baby if at all possible. For instance, a disease such as haemophilia almost always passes from mum to son.<\/p>\n\n\n\n We have learnt that particular gender selection is complex, it can be achieved by a small number of procedures, and it is sometimes governed by legislation and\/or regulatory guidance. The procedure is offered by treatment providers and requested by patients for many reasons and is opposed by individuals, religions, and whole societies (and we haven\u2019t really got into this reasoning) for complicated moral and ethical considerations. So, what do the fertility experts say?<\/p>\n\n\n\n The European Society of Human Reproduction and Embryology (ESHRE) maintains that gender selection should not be used for non-medical reasons, but it should be allowed in principle if it is aimed at avoiding offspring health risks and getting a healthy pregnancy. <\/p>\n\n\n\n ESHRE recommendations<\/strong><\/p>\n\n\n\n Source: ESHRE Task Force on ethics and Law 20: sex selection for non-medical reasons<\/a><\/em><\/p>\n\n\n\n\n
PGT-A and gender selection or whether is gender selection without IVF possible? <\/h2>\n\n\n\n
IVF gender selection\u2014countries where treatments are legal<\/h2>\n\n\n\n
Well, there are national variations and possibilities, and these are based around complex notions of ethics, morals, and legislation; sometimes these variations are obvious, sometimes not as the examples below show,<\/p>\n\n\n\n\n
Specific conditions in countries where gender selection IVF is legal<\/h2>\n\n\n\n
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\n\t \nLand<\/th> Sex selection - legal<\/th> Embryo sex on the PGT test result (not universal)<\/th>\n<\/tr>\n<\/thead>\n \n\t Spanien<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t Portugal<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t Tjekkiet<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t Gr\u00e6kenland<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t Nordcypern<\/td> No<\/td> Yes<\/td>\n<\/tr>\n \n\t Ukraine<\/td> No<\/td> Yes<\/td>\n<\/tr>\n \n\t Russia<\/td> No<\/td> Yes<\/td>\n<\/tr>\n \n\t Georgia<\/td> No<\/td> Yes<\/td>\n<\/tr>\n \n\t Letland<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t Polen<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t Det Forenede Kongerige<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t USA<\/td> Yes<\/td> Yes<\/td>\n<\/tr>\n \n\t Mexico<\/td> Yes<\/td> Yes<\/td>\n<\/tr>\n \n\t Canada<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t China<\/td> No<\/td> No<\/td>\n<\/tr>\n \n\t India <\/td> No<\/td> No<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n IVF gender selection costs<\/h2>\n\n\n\n
IVF gender selection dilemmas<\/h2>\n\n\n\n
IVF sex selection at fertility clinics<\/h3>\n\n\n\n
IVF sex selection\u2014the patient perspective<\/h3>\n\n\n\n
IVF for gender selection\u2014recommendations of international associations <\/h2>\n\n\n\n
European Society of Human Reproduction and Embryology<\/h3>\n\n\n\n
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American Society for Reproductive Medicine<\/h3>\n\n\n\n