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Possible solutions for when implantation failure means you do not get pregnant



Dr Rafael Bernabeu

When a couple attempts to get pregnant but does not manage to do so, particularly when gestation is not achieved following in vitro fertilisation (IVF) treatment with the couple’s own ova or with donated ova, it is essential that they avoid wasting any time and put themselves in the very best of hands because the problem is often due to implantation failure (although the embryo would not appear to have an anomaly of any kind, it does not implant in the uterus).

Years of experience with this matter naturally inspired Instituto Bernabeu, a leading entity in the field of avant-garde assisted reproduction, into setting up an Implantation Failure and Recurrent Pregnancy Loss Unit in 2009. The unit focuses specifically on these issues.

The solutions patients are given are always personalised to match their own particular needs. The unit feeds off a combined knowledge obtained through studying and treating hundreds of couples with this pathology during day-to-day work at the clinic, and intense scientific work that focuses on increasing knowledge of the nesting process in the third patient: the embryo and the response of the mother’s endometrium to the immunological invasion involved in accepting another being that is, furthermore, multiplying cells at a ferocious rate.

The unit is constantly making scientific progress and this is reinforced by publications in leading journals and acceptance for presentations in medical committees at leading international congresses.

Implantation failure studies should always begin with an analysis of the couple’s clinical data, taking into account family background and evaluating environmental exposure to toxins, lifestyle and so on. A high-resolution 3D ultrasound scan with powerful software is also essential in order to detect conditions that have a negative impact on nesting. For example, adenomyosis, a condition in the uterine cavity that generates embryo implantation failure and that has so far been difficult to diagnose.

After this, the team can assess a number of specific studies aimed at getting an in-depth understanding of the semen, the uterus, and the immune system. For example, vitamin D, phenylalanine hydroxylase (Phe) levels, thrombophilia analyses, sonohysterography and a possible biopsy on the endometrium in order to get an understanding of uterine receptivity, the genetic profile of associated chromosomes, possible DNA fragmentation, etc.

Once each couple’s individual profile has been examined, the multi-disciplinary team of specialists including gynaecologists, endocrinologists, geneticists and pharmacists designs a course of treatment that is adapted to the couple’s specific needs.

Another key factor in resolving implantation failure and premature pregnancy loss is a metabolic and genetic study of the embryo.

When using traditional means of analysis, an embryo can appear to be entirely morphologically normal, but a genetic study of the embryo is required in this group of patients because it provides much more concrete information, as well as avoiding the transfer of embryos which, despite looking perfect, will not lead to a successful pregnancy.

This analysis avoids the stress associated with unnecessary beta pregnancy tests that later end in embryo arrest. It also helps to get to the point of a successful pregnancy sooner because, as a result of having an understanding of chromosomal make-up thanks to the CCS-NGS technique, only embryos that are genetically normal are transferred.

In order to carry out an appropriate analysis of the embryo, as well as embryologists who are specialists in biopsies that cause no harm whatsoever to the surface of the blastocyst, Instituto Bernabeu has groundbreaking in-house genetics laboratories. This ensures speed and efficiency in diagnoses, as well as correct traceability in sample management.

Another important area of progress is the uterine contractility study used to optimise the best time and place in the endometrium for facilitating embryo nesting when the time has come to transfer to the mother.

Whilst this group of patients remains a complex one because there is still a lot to be learnt about the mystery of embryo implantation, progress at Instituto Bernabeu is opening up a door of hope that has made it possible to form thousands of new families.

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Get Answers To All Your Questions About Donor Sperm At The Fertility Show London




The world’s largest sperm bank, Cryos International, is attending The Fertility Show London on the 3rd and 4th of November 2018. The event is for everyone who dreams of starting a family and seeks information on the subject. The Fertility Show London is the biggest live event where you can meet with top fertility experts and patients alike. Every year, The Fertility Show London has thousands of visitors who use the event as a place of learning and discovery before embarking on their fertility journeys. Cryos will be there to guide you at our stand H34.

What to expect:
At the London Fertility Show, you will have the opportunity to participate in a comprehensive seminar program with over 50 lectures by leading experts, to visit exhibitors’ information stands to get the chance to speak face to face with clinics, doctors and specialists in fertility, and to meet like-minded people, who have made the same decisions as you and want to share their experience.

You will have the opportunity to:

  • ask your individual questions
  • meet specialists in person
  • get informed about the latest fertility research
  • hear from others who have been in your situation
  • learn more about safe fertility treatment
  • get advice from leading experts on and off stage
  • have a personal conversation with Cryos about your needs

Valid information and a safe environment
There is a lot of information available on the internet and you will probably spend months investigating the different options. Some of this information is unreliable or risky. Do not leave the most important decision in your life to chance. At the Fertility Show London you can be sure that all information is scientifically validated.

The event will be conducted in a discreet and safe environment with no name badges so that you can feel comfortable asking questions and exploring your options for your fertility journey.

Visit Cryos’ stand
Cryos is the world’s largest sperm bank with the largest selection of sperm donors to choose from. We have more than 30 years of experience and we would love to share that knowledge with you. Visit Cryos’ stand H34 for an informal conversation and we will personally help guide you through your decisions.

Visit Cryos’ website here

We look forward to seeing you at our stand at The Fertility Show London 2018.

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The New Fertility Blog – by Cryos International



The New Fertility Blog – by Cryos International

The world’s largest sperm bank, Cryos International, has started a fertility blog to provide you with all the information that you need.

The blog is packed with exciting blog posts about donor sperm, other people’s experiences, pregnancy and a lot of other topics relevant for your fertility journey.

Who are we and why follow our blog?
Cryos started back in the 80’s with the vision to help childless make their dream of a child come true and is today, 30 years later, the world’s largest sperm bank. We take pride in the responsibility of helping create life as we believe that everyone should have the chance to experience the joy of parenthood.

We want to create awareness and offer information about infertility and fertility treatment with donor sperm and the fertility blog is an effort to do so.

The blog is for you who wants to know more about:

  • Donor children
  • Donor sperm
  • Fertility treatment
  • Pregnancy
  • Other people’s experiences with fertility treatment and having donor conceived children
  • And about Cryos in general

We will guide you through all the fertility terms and help you in your fertility journey by giving your advice on for example how to choose the right sperm donor, how to order the donor sperm, which fertility treatment you should use and a much much more. We have also gathered information about other people’s personal experiences and stories.

Visit the blog here

Please don’t hesitate to comment our blog posts and join the conversation.

Follow us on Facebook and join our online community
You can also follow us on Facebook and join our Online Community, Family Dreams, where you can share your experiences and connect with like-minded people.

See you at Cryos’ Blog and/or Family Dreams. ?

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Instituto Bernabeu, a pioneer since 2014 in guaranteeing pregnancy up until childbirth or money back



Instituto Bernabeu, a pioneer since 2014 in guaranteeing pregnancy up until childbirth or money back

?He’s got brown eyes, dark skin and curly hair, just like his mother. He started school this year. Time flies! Jorge is three years old now and for Ana and Jorge, his parents, he is the love of their lives. Just like any child his age, Jorge runs, plays and tires his parents out. They happily admit that their tiredness is the happiest and most longed for tiredness in the world.

In 2014, the couple put their faith in the Pregnancy Guarantee programme that provides coverage up until childbirth, as pioneered in Europe by Instituto Bernabeu. It revolutionised the market by guaranteeing pregnancy in women who are unable to get pregnant naturally and returning the amount paid if, in the end, the objective is not achieved.

Ana was 43 years old, the maximum age for participating in the Combined Guarantee option that includes one course of in vitro fertilisation treatment (IVF) with the patient’s own ova and donated oocytes in posterior cycles. When she came to the clinic, she was worn out following several courses of treatment in other clinics and somewhat desperate since time was going by and the couple had not received the miracle they so longed for. However, she was also hopeful on hearing that everything was under control and that she had 18 months in order to give it a go. Furthermore, the couple was fully aware of how much it was going to cost and knew that there would not be any unwanted surprises down the line. For Ana, the fact that the clinic was committed to her with a money back clause was a guarantee of the clinic’s commitment to achieving pregnancy up until childbirth. The gynaecologist’s words stuck in her mind: we’re on this journey together.

The fact that the programme includes the necessary ultrasound scans, analyses, check-ups and tests during the cycles with no unexpected additional costs put Ana at ease. The Pregnancy Guarantee programmes includes three cycles of assisted reproduction treatment and all the frozen embryo transfers.

From the moment they walked through the door, the couple felt that they were important and that they had become part of the Instituto Bernabeu family. As well as patients, they were Ana and Jorge and their particular case and characteristics became unique. They felt special.

The team of healthcare professionals studied their case and recommended the IVF Combined Guarantee programme using donated oocytes. They also informed the couple about the IVF Combined Guarantee programme involving embryo donation. Whilst this was not necessary in their case, the couple knew that the clinic offers a guarantee exclusively for egg donation for women up to 49 years of age.

The Pregnancy Guarantee programme includes several criteria that put couples at ease. The very first step in all courses of treatment is to study the case. This includes the necessary consultations, ultrasound scans, analyses and sperm analyses.

Whenever the team of doctors believes it is necessary, comprehensive chromosome screening of embryos using CCS-NGS, as well as vitrification of the ones obtained during treatment and freezing for a period of 2 years, is carried out. Sperm sample freezing and maintenance for the duration of the programme is also included.
In the laboratory, embryologists and molecular biologists perform the techniques that give the best results. This includes spermatozoa selection using various methods as well as the use of time lapse incubation systems.

A maximum of two embryos are transferred per cycle. Instituto Bernabeu does not encourage multiple pregnancies because they involve increased complications both for the mother and for the babies. In future mothers aged over 45, the clinic never recommends transfer of more than one embryo because Instituto Bernabeu is not interested in a result no matter what the consequences; it is interested in healthy maternity and babies.

Services include being able to enjoy a massage or acupuncture over the days leading up to embryo transfer. If the specialist believes it is necessary, endometrial scratching can also be carried out.

In Ana’s case, the embryo implanted quickly. She got a positive beta pregnancy test three months after starting treatment. She looks back on that day with emotion and happiness. Every day that went by was a ray of hope and also uncertainty. She wanted the baby that was growing inside her to continue doing so and she felt supported and listened to all the way through because the clinic showed an interest in how she was getting on. Each case is different and, just like Ana, many other patients have become mothers thanks to this programme because of the peace of mind and guarantee it provides. Other patients have taken longer to reach their goal whilst others have even lost the embryo and, after taking the necessary time to come up for air, they have tried once again to fulfil their dream with the support of a programme that aims for a viable pregnancy. The clinic is committed to its patients.

Pregnancy loss or situations such as missed abortions do not annul the guarantee. Just like the patient, the clinic aims for the birth of a healthy child.
Jorge was born in May and one month later Ana and Jorge visited Instituto Bernabeu in order to show everyone their baby. It was then that they confessed that they were no longer Ana and Jorge; now they were Jorge’s parents.

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