Embryo Monitoring – Real Patient Cases

IVF Success Stories

Facing infertility challenges can be emotionally draining for couples dreaming of parenthood. However, with the assistance of cutting-edge reproductive technologies, fertility clinics like Clínica Tambre are offering renewed hope and improved outcomes. In this article, we explore the remarkable success stories of patients who achieved pregnancy by employing specialized techniques such as sperm selection using “Chip Fertile” and embryo monitoring through “Geri Time Lapse technology”

What is Embryo Monitoring?

Embryo monitoring refers to the process of closely observing and assessing the development of embryos during in vitro fertilization (IVF) or other assisted reproductive procedures. It involves utilizing advanced imaging technologies and time-lapse systems to capture continuous images or videos of embryos as they grow and divide in the laboratory.

Traditionally, embryos in IVF were evaluated periodically, usually once or twice a day, by removing them from the incubator and examining them under a microscope. This limited the amount of information available to embryologists and required frequent disturbances to the controlled environment in which the embryos were kept.

With embryo monitoring, however, a time-lapse system is used to capture images of embryos at regular intervals without disturbing their environment. These images are then compiled into a time-lapse video, allowing embryologists to observe the development of embryos in real-time and gather detailed information about their growth patterns, cell divisions, and other crucial parameters.

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Embryo monitoring offers several benefits in the field of reproductive medicine. It allows embryologists to assess the quality and viability of embryos more accurately, as they can observe key developmental milestones and detect any abnormalities or irregularities that may affect their potential for implantation. This information helps fertility specialists make informed decisions regarding embryo selection and transfer, optimizing the chances of a successful pregnancy.

Furthermore, embryo monitoring can provide valuable insights into the timing of embryo development, allowing for better synchronization with the woman’s uterine lining and increasing the likelihood of successful implantation.

In this article, we delve into the remarkable technique of embryo monitoring and explore two real patient stories from the renowned fertility clinic, Clínica Tambre.

37 and 42 years old couple, two unsuccessful IVF cycles

  • 37-year-old female, 42 years old male partner
  • 2 IVF cycles failed
  • DNA sperm fragmentation ≥ 40%

General Description of the Case

The patient, a 37-year-old female, and her 42-year-old male partner had undergone two unsuccessful IVF cycles with ICSI in London. Despite having only two embryos available for transfer in the previous treatment, the patient had a normal ovarian reserve and a successful prior pregnancy with her current husband three years ago. A DNA Fragmentation test revealed a significant issue of high DNA Fragmentation Index (DFI ≥ 40%).

Diagnostic Findings

The diagnosis for this patient included low ovarian reserve and male infertility due to high DNA Fragmentation, resulting in a lack of transferable embryos post-fertilization.

Protocols and Procedures

At Clínica Tambre, the medical director, Dr Laura Garcia de Miguel, recommended fertilization with fresh sperm using the “Chip Fertile” technique, which selectively selects the least fragmented sperm for fertilization with the patient’s fresh eggs. Additionally, the patient underwent embryo monitoring with “Geri Time Lapse technology.” This innovative method mimics a woman’s uterus in an incubator, allowing embryos to develop undisturbed until they reach the blastocyst stage. This approach not only increases the number of transferable embryos by approximately 20% but also provides valuable data to predict the most viable embryos for transfer.

Results and Embryo Transfer

Following the procedures, the patient obtained three good-quality blastocysts (BT3AA, BT3AB, BT3BA, BT3BB, BT2AA, BT2AB, BT2BA, BT2BB). The selected embryo was transferred to the patient, resulting in a positive pregnancy test. The patient is currently 34 weeks pregnant, and her pregnancy is progressing smoothly.

Patient’s Unique Situation:

The case of this patient, including her age, multiple failed treatments, and specific medical conditions, represents a common scenario among fertility clinic patients. It highlights the importance of a comprehensive diagnostic approach and personalized treatment based on the individual’s medical history.

Doctor’s Perspective

According to Dr Laura Garcia de Miguel, it is crucial to investigate and address all potential factors contributing to unsuccessful cycles. In this case, identifying the male factor through the DNA Fragmentation test was essential in designing an optimized treatment plan. By avoiding the fertilization of oocytes that may not result in transferable embryos, the clinic ensures that the patient’s time and financial investments are not in vain. Personalized treatments based on scientific assessments are pivotal in achieving successful outcomes.

Conclusion

The success story of this UK patient underscores the transformative potential of advanced reproductive technologies and personalized care offered by the clinic. Through innovative techniques like “Chip Fertile” and “Geri Time Lapse technology,” the clinic addresses unique challenges, enhances embryo selection, and improves pregnancy rates.

32 years old female, 31 years old male partner, four unsuccessful IUI treatments

  • 32 years old female patient, 31 years old male partner
  • 4 IUI failed
  • previous pregnancy at 20
  • normal AMH level – 2.75

General Description of the Case

A 32-year-old female patient and her 31-year-old male partner had undergone four unsuccessful IUI treatments. In their last treatment, the patient obtained four embryos for transfer. The patient had a previous pregnancy at the age of 20, but it resulted in an abortion. She had a normal ovarian reserve with an AMH level of 2.75 ng/ml.

Diagnostic Findings

The patient’s diagnosis revealed a low response to stimulation during previous treatments, resulting in only three embryos retrieved in the Netherlands. However, the male partner showed normal fertility status.

Protocols and Procedures

Under the guidance of Dr Laura Garcia de Miguel, the medical director at Clínica Tambre, the treatment plan involved fertilization with fresh sperm while keeping the frozen sample as a backup option. Additionally, the patient underwent PGT-A (Preimplantation Genetic Testing for Aneuploidy) along with Geri Time Lapse technology. Geri Time Lapse technology provided a safe and undisturbed environment within an incubator that mimicked a woman’s uterus, allowing optimal embryo development and selection.

Results and Embryo Transfer:

Following the recommended procedures, the patient obtained five high-quality blastocysts (BT6AA, BT6AA, BT6BA, BT6CB, BT5CB). PGT-A analysis identified three euploid embryos. The embryo BT6AA was selected and transferred to the patient, leading to a positive pregnancy result. The patient is currently 26 weeks pregnant.

Patient’s Unique Situation:

This case highlights the common challenges couples face undergoing fertility treatments, including multiple failed attempts and low ovarian response. It emphasizes the importance of personalised treatment protocols and comprehensive diagnostic evaluations in optimizing outcomes.

Doctor’s Perspective

According to Dr Laura Garcia de Miguel, thorough preparation before embryo transfer, such as conducting a DNA Fragmentation test, Geri Time Lapse monitoring, and PGT-A analysis, is critical. These measures help identify and exclude potentially non-transferable embryos, allowing for personalized adjustments in treatment protocols based on individual patient history and scientific analysis.

Conclusion

The remarkable journey of this Dutch patient showcases the transformative impact of advanced reproductive technologies and individualized care provided by the clinic. By combining techniques like PGT-A and Geri Time Lapse technology, the clinic offers tailored treatment plans that improve success rates and increase the chances of a positive pregnancy outcome.

Please note: This case study is for informational purposes only and should not replace professional medical advice. The success rates and outcomes mentioned here are specific to this case and may not reflect the results of every individual undergoing similar treatment.

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    Editorial Team
    Editorial Team
    Fertility Road aims to inform and inspire in a manner which is honest, direct and empathetic. Our worldwide expert writers break down the science and deliver relevant, up-to-date insights into everything related to IVF.

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